Holders Wigan drawn against Tigers
Wigan will face the stiffest test so far in their defence of the Tetley's Challenge Cup after being paired with Super League surprise packet Castleford in the quarter-finals.
The Warriors strolled into the last eight on the back of comfortable victories over part-time opponents Dewsbury and Hunslet but they will be preparing for a stiff examination against Dary Powell's Castleford, who beat them 3 6-31 at the Jungle in the league last month.
The Tigers are second in the table after winning eight of their first 10 matches but Wigan will have home advantage in the stand-out quarter-final tie, which will be played on the weekend of June 7-8.
The draw, made by Great Britain internationals Jason Robinson and Paul Sculthorpe, threw up only one other all-Super League tie, with Bradford hosting Warrington. The two meet at Odsal in a dress rehearsal on Sunday.
The odds on Leeds winning the Cup for the first time since 1999 shortened when they were drawn at home to Championship leaders Leigh - only their second tie against non Super League opposition since 2010 - while Widnes will be strong favourites to reach the semi-finals after being drawn at home to the other part-time outfit, Keighley.
Powell says his side will travel to Wigan with confidence, especially after gaining a 42-38 win on their last visit to the DW Stadium last August.
"It's a tough draw but we've had it pretty comfortable so far with a couple of Championship sides, so you can't complain too much when you get a difficult one," Powell said.
"If you're going to win something you have to beat good sides. We'll go there with a bit of confidence. We've beaten Wigan the last two times we've played them, so there's no reason to fear it too much. We just need to go and play.
"There's a bit of time before the game so you don't know what the form line of both teams is going to be at that point, but our form is good.
"We feel that we've got a chance no matter who we are playing this season. It's a one-off game."